Psychedelic Safety & Harm Reduction

Before: Preparation

• Clarify intention. Why are you doing this? What do you hope to explore or release?
• Choose a safe, comfortable, private environment (or licensed service center where legal).
• Arrange a trusted, sober sitter or guide — especially for doses above micro.
• Review medical/psychiatric contraindications (personal or family history of psychosis, unstable bipolar, certain medications like SSRIs/MAOIs — research interactions).
• Test your substances. Use reagent kits (Marquis, Ehrlich, etc.) and fentanyl test strips. Services: DanceSafe.

During: The Experience

• Start low, go slow. You can always take more later (but not the reverse).
• Stay hydrated and have light snacks. Avoid alcohol and other substances.
• Have a “playlist” or quiet space ready. Music without lyrics is often preferred in research settings.
• Challenging moments are common and often meaningful. Breathe, change position, remind yourself “this will pass.”
• Real-time support: Call or text the Fireside Project peer support line at (623) 473-7433 (available many hours).
• For severe distress: Zendo Project or local emergency services if physical symptoms are concerning.

After: Integration

The days and weeks after are when lasting change happens — or doesn’t.

• Journal insights while fresh. Note emotions, memories, or shifts in perspective.
• Rest and protect sleep. Many report a “afterglow” period of increased openness.
• Consider professional integration support or a psychedelic-informed therapist.
• Allow 2–4 weeks before another full dose. Frequent use diminishes returns and increases risks.
• Resources: Zendo Project (integration + support), MAPS resources, local circles where available.